By oocyte fertilization an embryo comes into existence. Unfortunately, it is impossible to ensure that the connection between a sperm cell and an egg develops only into perfect embryos. How the genetic information from the mother and father mixes inside the egg cannot be influenced by science. It is a matter of coincidence.
Prolonged cultivation of embryos is the most basic method to distinguish between healthy and imperfect embryos. Completely defective embryos stop developing during the first five days in the laboratory. Embryos that continue to develop until day 5 are considered good. One, maximum two, embryos will be transferred into the uterus, and the remaining good quality embryos can be cryopreserved.
During natural pregnancy, the concentration of hyaluronan in the uterus increases. During assisted reproduction, it is suitable to add this substance. EmbryoGlue®, thanks to its high content of hyaluronan, simply said, “sticks” the embryo to the uterine wall. Hyaluronan also thickens the solution of EmbryoGlue®, making it similar in consistency to uterine fluid. This minimizes undesirable movements of the embryo.
When implanting fertilized eggs, we use EmbryoGlue®, which has been proven to increase the number of pregnancies and the number of children born. EmbryoGlue is a tissue adhesive that naturally mimics the environment in the uterus during natural embryo implantation. Simply put – EmbryoGlue® helps good attachment of the fertilized egg to the wall of the uterus.
In 2008, the results of a study involving over 1200 women in 2006-2007 were published. With the use of standard transfer medium, 48% of patients became pregnant. If women received EmbryoGlue®, the pregnancy rate increased to 54.6%. According to the study by Dr. Basak Balaban, presented in 2011 at ESHRE (European Society of Human Reproduction and Embryology), the number of children born with EmbryoGlue® use increased by 11.2%.
EmbryoGlue contains carbohydrates and amino acids which support the embryo during transfer and attachment to the uterine lining, hyaluronan, and recombinant albumin, which minimizes the risk of cross-contamination.
When there is an increased risk of congenital genetic diseases, we can assess the chromosomal genetic characteristics of the embryo using the PGD (Pre-implantation Genetic Diagnosis) method and avoid transferring affected embryos.
