Contact

CD 138

CD 138 (syndecan1) is a protein that accumulates on the surface of plasma cells. If we find an excess of them in the uterine lining, it indicates chronic endometritis – a longterm, often asymptomatic inflammation that can reduce the chance of successful embryo implantation and increase the risk of early miscarriage.

Read more
Contact us

When we recommend testing


  • Multiple failed embryo transfers of goodquality embryos
  • Recurrent miscarriages before the 12th week of pregnancy
  • Unexplained infertility lasting longer than 12 months
  • Irregular spotting or bleeding outside the menstrual cycle

How the test is performed

  1. Sample collection – a thin plastic pipelle is inserted in the uterus to collect an endometrial sample
  2. Laboratory staining – the tissue is stained with an antibody that highlights CD 138; plasma cells are then clearly visible under the microscope
  3. Pathologist evaluation – the number of CD 138positive cells is counted and chronic endometritis is diagnosed. 

After the procedure you can go home right away and drive normally.

Treatment of chronic endometritis


  • Targeted antibiotics based on the most common bacterial findings
  • Support of the vaginal microbiome (probiotics, gentle hygiene habits)

Clinical studies show that successful treatment of chronic endometritis can increase the likelihood of embryo implantation.

Form

Ask specialist

Kontakt

Dear patients,
due to the public holiday in the Czech Republic, our clinic will be closed on 28/10/25.

We look forward to seeing you again on Wednesday 29/10/25.