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ZyMōt - Microfluidic Sperm Sorting

REVOLUTIONARY SPERM SELECTION METHOD BY ZYMŌT MICROFLUID CHIPS

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Microfluidic Sperm Sorting

Microfluidic Sperm Sorting is a chemical free method of sperm selection using a disposable chip. The method is based on the principle of natural sperm selection in a passage through micro-barriers imitating natural environment of female reproductive system.

  • maximum imitation of the natural sperm selection mechanism
  • selection of only high quality and healthy sperm with intact DNA
  • significant increase in pregnancy success rate
  • significant reduction in the risk of miscarriage

Microfluidic Sperm Sorting is a modern gentle alternative to standard sperm selection process which does not require any previous processing of sperm sample or use of devices such as centrifugation that increase oxidative stress in sperm.

MICROFLUIDIC SPERM SORTING METHOD IN PRACTICE

To select best quality healthy sperm for the artificial insemination process (IVF) significantly affects the chance of a successful pregnancy. During natural fertilization process, healthy sperm are separated from others in microfluidic channels occurring naturally in the woman’s reproductive system.

In IVF treatment, this natural mechanism of the body (sperm selection) is mimicked through microfluidic chips. Microfluidic chips have been developed to completely mimic the natural mechanism of sperm selection in a laboratory setting. These microchannels work as a filter that selects only healthy and high quality sperm.

The chip has an inlet for the sample, which is linked to the outlet opening with a microfluidic duct. The untreated sperm is introduced into the inflow and only motile and morphologically normal sperm are able to swim through the chip to the outflow where it is collected for use. The selected sperms exhibit better morphology, genetic quality and double the viability and motility of unsorted sperms.

This method increases the success of a cycle by up to 25%.

INDICATIONS FOR MICROFLUIDIC SPERM SORTING

  • recurring IUI failure
  • egg fertilization low rate with ICSI in the previous cycle
  • recurring miscarriage
  • recurring embryo implantation fail
  • poor-quality embryos in previous IVF cycle
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