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EM - Embryomonitoring (EmbryoScope)

POTENTIAL OF AI-BASED EMBRYO EVALUATION
THE BEST-QUALITY EMBRYO SELECTION FOR TRANSFER IN IVF PLAYS MAJOR ROLE IN ACHIEVING HIGH PREGNANCY RATES.

The potential of artificial intelligence to improve processes in IVF is immense. For example, artificial intelligence can be used to automate repetitive tasks which may be prone to human-derived subjectivity and variability.

A perfect example is the process of embryo selection where embryos in a cohort need to be prioritised for transfer or cryopreservation according to their predicted viability.

Guided Annotation is the most modern tool for the embryo assessment process and makes use of deep learning-based algorithms to automatically estimate cell division events, PN number and blastocyst morphology, resulting in a streamlined and efficient full embryo assessment workflow.

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TIME-LAPSE TECHNOLOGY REDUCES OBSERVATIONAL TIME RESTRICTIONS AND STRESS TO EMBRYOS DURING CULTURE AND ASSESSMENT.

WITH TIME-LAPSE YOU CAN ENJOY UNDISTURBED CULTURE AND CONTINUOUS IMAGE ACQUISITION AND IMPROVE YOUR SELECTION PROCESS THROUGH A MORE OBJECTIVE ANALYSIS.

Semi-continuous monitoring of embryos is a method whose aim is to monitor the embryo development in the incubator. In fact, this revolutionary system gives us an opportunity of significant “insight” into the whole embryo development. It helps us to select the most suitable embryo(s) to be transferred into the uterus to cause a pregnancy.

The introduction of this optical system in incubators gives us a chance to let embryos develop undisturbed during the entire culture period and they do not need to be tested outside the incubator.

Embryo monitoring is a continuous recording of extracorporeal embryo development and represents the most modern method of in vitro cultivation.

In the time lapse incubator called Embryoscope, the embryos are placed in individual wells of a special culture dish and a photo of the embryos is taken regulary. The images are automatically stored and made into a continuous data record. Throughout their development embryos remain safe and undisturbed inside the incubator. The fewer disturbances your embryos receive, the more likely they are to develop somewhat as close to they should in their natural environment of the womb. Embryoscope continually monitors the embryos and indicates if they are dividing correctly and within set time frames.

Years of research and development

The key events in embryonic development should happen at specific time points. Some embryos can develop too fast or too slow, sometimes abnormal division of the cells occurs and abnormalities can form. Time lapse imaging helps in choosing the embryo with the highest implantation potential.

Embryologists will grade embryos on the number of cells, their shape, level of fragmentation, thickness of the outer shell etc.

Without embryo monitoring equipment embryologists may assess an aneuploid embryo to be normal and decide that it is suitable for transfer. But, of course, it may not be normal. If it is abnormal, it may not implant or may lead to a miscarriage. With embryo monitoring, an embryologist has lots of information on how the embryo divides, what it looks like whilst dividing etc. This information can be used to assess whether a normal looking embryo is indeed ‘normal’.

Time-lapse embryo monitoring can also sometimes determine early on which embryos are most likely to make it to the blastocyst stage. This may mean that we can transfer embryos earlier in the knowledge that the best ones have been chosen.

ARE THERE ANY RISKS RELATED TO EMRYOMONITORING?

There are no known risks associated with monitoring. The facility operates in the same manner as the standard incubator that is always used for the cultivation of embryos.

Reasons for embryo monitoring

  • Spermiogram results at the lower limits of standards
  • Low success rate after ICSI
  • Low embryo viability in the previous cycle
  • History of abortion
  • Advanced age women
  • Recipient of a donated egg
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